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Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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Title: Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Authors: Perez-Cornago, A
Travis, RC
Appleby, PN
Tsilidis, KK
Tjonneland, A
Olsen, A
Overvad, K
Katzke, V
Kuhn, T
Trichopoulou, A
Peppa, E
Kritikou, M
Sieri, S
Palli, D
Sacerdote, C
Tumino, R
Bueno-de-Mesquita, HB
Agudo, A
Larranaga, N
Molina-Portillo, E
Ardanaz, E
Chirlaque, MD
Lasheras, C
Stattin, P
Wennberg, M
Drake, I
Malm, J
Schmidt, JA
Khaw, KT
Gunter, M
Freisling, H
Huybrechts, I
Aune, D
Cross, AJ
Riboli, E
Key, TJ
Item Type: Journal Article
Abstract: Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up time of 13.9 years, 7,036 prostate cancer cases were identified. Compared with the lowest fifth, those in the highest fifth of total fruit intake had a significantly reduced prostate cancer risk (HR = 0.91; 95% CI = 0.83–0.99; p-trend = 0.01). No associations between fruit subtypes and prostate cancer risk were observed, except for citrus fruits, where a significant trend was found (HR = 0.94; 95% CI = 0.86–1.02; p-trend = 0.01). No associations between total and subtypes of vegetables and prostate cancer risk were observed. We found no evidence of heterogeneity in these associations by tumor grade and stage, with the exception of significant heterogeneity by tumor grade (pheterogeneity<0.001) for leafy vegetables. No significant associations with prostate cancer death were observed. The main finding of this prospective study was that a higher fruit intake was associated with a small reduction in prostate cancer risk. Whether this association is causal remains unclear.
Issue Date: 15-May-2017
Date of Acceptance: 27-Mar-2017
URI: http://hdl.handle.net/10044/1/46114
DOI: https://dx.doi.org/10.1002/ijc.30741
ISSN: 1097-0215
Publisher: Wiley
Start Page: 287
End Page: 297
Journal / Book Title: International Journal of Cancer
Volume: 141
Issue: 2
Copyright Statement: © 2017 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: fruit
prospective
prostate cancer
tumor subtypes
vegetable
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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