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Effects of dyslipidaemia on monocyte production and function in cardiovascular disease.

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Title: Effects of dyslipidaemia on monocyte production and function in cardiovascular disease.
Authors: Rahman, MS
Murphy, AJ
Woollard, KJ
Item Type: Journal Article
Abstract: Monocytes are heterogeneous effector cells involved in the maintenance and restoration of tissue integrity. Monocytes and macrophages are involved in cardiovascular disease progression, and are associated with the development of unstable atherosclerotic plaques. Hyperlipidaemia can accelerate cardiovascular disease progression. However, monocyte responses to hyperlipidaemia are poorly understood. In the past decade, accumulating data describe the relationship between the dynamic blood lipid environment and the heterogeneous circulating monocyte pool, which might have profound consequences for cardiovascular disease. In this Review, we explore the updated view of monocytes in cardiovascular disease and their relationship with macrophages in promoting the homeostatic and inflammatory responses related to atherosclerosis. We describe the different definitions of dyslipidaemia, highlight current theories on the ontogeny of monocyte heterogeneity, discuss how dyslipidaemia might alter monocyte production, and explore the mechanistic interface linking dyslipidaemia with monocyte effector functions, such as migration and the inflammatory response. Finally, we discuss the role of dietary and endogenous lipid species in mediating dyslipidaemic responses, and the role of these lipids in promoting the risk of cardiovascular disease through modulation of monocyte behaviour.
Issue Date: 16-Mar-2017
Date of Acceptance: 1-Mar-2017
URI: http://hdl.handle.net/10044/1/46055
DOI: https://dx.doi.org/10.1038/nrcardio.2017.34
ISSN: 1759-5010
Publisher: Nature Publishing Group
Start Page: 387
End Page: 400
Journal / Book Title: Nature Reviews Cardiology
Volume: 14
Copyright Statement: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The final publication is available at https://dx.doi.org/10.1038/nrcardio.2017.34
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: FS/14/50/30856
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
HIGH-DENSITY-LIPOPROTEIN
CORONARY-ARTERY-DISEASE
STEM-CELL PROLIFERATION
TRIGLYCERIDE-RICH LIPOPROTEINS
RETINYL PALMITATE RESPONSES
GENE-EXPRESSION PROFILES
BLOOD MONONUCLEAR-CELLS
ISCHEMIC-HEART-DISEASE
SATURATED FATTY-ACIDS
APOE-DEFICIENT MICE
Cardiovascular System & Hematology
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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