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Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans

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Title: Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
Authors: Stepien, M
Hughes, DJ
Hybsier, S
Bamia, C
Tjonneland, A
Overvad, K
Affret, A
His, M
Boutron-Ruault, M-C
Katzke, V
Kuehn, T
Aleksandrova, K
Trichopoulou, A
Lagiou, P
Orfanos, P
Palli, D
Sieri, S
Tumino, R
Ricceri, F
Panico, S
Bueno-de-Mesquita, HBA
Peeters, PH
Weiderpass, E
Lasheras, C
Bonet Bonet, C
Molina-Portillo, E
Dorronsoro, M
Maria Huerta, J
Barricarte, A
Ohlsson, B
Sjoberg, K
Werner, M
Shungin, D
Wareham, N
Khaw, K-T
Travis, RC
Freisling, H
Cross, AJ
Schomburg, L
Jenab, M
Item Type: Journal Article
Abstract: background: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. methods: A nested case–control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. results: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13–0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45–2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41–15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed. conclusions: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
Issue Date: 2-Feb-2017
Date of Acceptance: 4-Jan-2017
URI: http://hdl.handle.net/10044/1/45839
DOI: http://dx.doi.org/10.1038/bjc.2017.1
ISSN: 1532-1827
Publisher: Cancer Research UK
Start Page: 688
End Page: 696
Journal / Book Title: British Journal of Cancer
Volume: 116
Issue: 5
Copyright Statement: © 2017 Cancer Research UK
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
copper
zinc
hepatocellular carcinoma
prospective cohort
nested case-control study
cancer risk factors
FATTY LIVER-DISEASE
HEPATOCELLULAR-CARCINOMA
OXIDATIVE STRESS
SERUM COPPER
HEPATITIS-C
BILIARY-TRACT
INFLAMMATION
COHORT
RATIO
CERULOPLASMIN
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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