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The diagnosis and evaluation of dilated cardiomyopathy

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Title: The diagnosis and evaluation of dilated cardiomyopathy
Authors: Japp, AG
Gulati, A
Cook, SA
Cowie, MR
Prasad, SK
Item Type: Journal Article
Abstract: Dilated cardiomyopathy (DCM) is best understood as the final common response of myocardium to diverse genetic and environmental insults. A rigorous work-up can exclude alternative causes of left ventricular (LV) dilation and dysfunction, identify etiologies that may respond to specific treatments, and guide family screening. A significant proportion of DCM cases have an underlying genetic or inflammatory basis. Measurement of LV size and ejection fraction remain central to diagnosis, risk stratification, and treatment, but other aspects of cardiac remodeling inform prognosis and carry therapeutic implications. Assessment of myocardial fibrosis predicts both risk of sudden cardiac death and likelihood of LV functional recovery, and has significant potential to guide patient selection for cardioverter-defibrillator implantation. Detailed mitral valve assessment is likely to assume increasing importance with the emergence of percutaneous interventions for functional mitral regurgitation. Detection of pre-clinical DCM could substantially reduce morbidity and mortality by allowing early instigation of cardioprotective therapy.
Issue Date: 20-Jun-2016
Date of Acceptance: 21-Mar-2016
URI: http://hdl.handle.net/10044/1/45801
DOI: https://dx.doi.org/10.1016/j.jacc.2016.03.590
ISSN: 1558-3597
Publisher: Elsevier
Start Page: 2996
End Page: 3010
Journal / Book Title: Journal of the American College of Cardiology
Volume: 67
Issue: 25
Copyright Statement: © 2016 by the American College of Cardiology Foundation. Published by Elseiver. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
imaging
implantable cardioverter-defibrillator
remodeling
CARDIAC-RESYNCHRONIZATION THERAPY
CARDIOVASCULAR MAGNETIC-RESONANCE
FUNCTIONAL MITRAL REGURGITATION
RANDOMIZED CONTROLLED-TRIALS
CARDIOLOGY WORKING GROUP
COLLEGE-OF-CARDIOLOGY
CHRONIC HEART-FAILURE
NONISCHEMIC CARDIOMYOPATHY
EUROPEAN-SOCIETY
MYOCARDIAL FIBROSIS
Cardiovascular System & Hematology
1102 Cardiovascular Medicine And Haematology
1117 Public Health And Health Services
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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