Ocular tremor in Parkinson’s disease: discussion, debate, and controversy

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Title: Ocular tremor in Parkinson’s disease: discussion, debate, and controversy
Author(s): Kaski, D
Bronstein, AM
Item Type: Journal Article
Abstract: The identification of ocular tremor in a small cohort of patients with Parkinson’s disease (PD) had lay somewhat dormant until the recent report of a pervasive ocular tremor as a universal finding in a large PD cohort that was, however, generally absent from a cohort of age-matched healthy subjects. The reported tremor had frequency characteristics similar to those of PD limb tremor, but the amplitude and frequency of the tremor did not correlate with clinical tremor ratings. Much controversy ensued as to the origin of such a tremor, and specifically as to whether a pervasive ocular tremor was a fundamental feature of PD, or rather a compensatory eye oscillation secondary to a transmitted head tremor, and thus a measure of a normal vestibulo-ocular reflex. In this mini review, we summarize some of the evidence for and against the case for a pervasive ocular tremor in PD and suggest future experiments that may help resolve these conflicting opinions.
Publication Date: 24-Apr-2017
Date of Acceptance: 21-Mar-2017
URI: http://hdl.handle.net/10044/1/45775
DOI: https://dx.doi.org/10.3389/fneur.2017.00134
ISSN: 1664-2295
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Neurology
Volume: 8
Copyright Statement: © 2017 Kaski and Bronstein. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Medical Research Council (MRC)
Imperial College Trust
Funder's Grant Number: G0701698
Keywords: Parkinson’s disease
eye oscillations
head tremor
ocular tremor
vestibulo-ocular reflex
1109 Neurosciences
1103 Clinical Sciences
1701 Psychology
Publication Status: Published
Article Number: 134
Appears in Collections:Department of Medicine
Faculty of Medicine

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