The hair follicle: an underutilized source of cells and materials for regenerative medicine

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Title: The hair follicle: an underutilized source of cells and materials for regenerative medicine
Author(s): Kiani, MT
Higgins, CA
Almquist, BD
Item Type: Journal Article
Abstract: The hair follicle is one of only two structures within the adult body that selectively degenerates and regenerates, making it an intriguing organ to study and use for regenerative medicine. Hair follicles have been shown to influence wound healing, angiogenesis and neurogenesis, and harbor distinct populations of stem cells; this has led to cells from the follicle being used in clinical trials for tendinosis and chronic ulcers. In addition, keratin produced by the follicle in the form of a hair fiber provides an abundant source of biomaterials for regenerative medicine. In this review, we provide an overview of the structure of a hair follicle, explain the role of the follicle in regulating the microenvironment of skin and the impact on wound healing, explore individual cell types of interest for regenerative medicine, and cover several applications of keratin-based biomaterials.
Publication Date: 21-Mar-2017
Date of Acceptance: 21-Mar-2017
URI: http://hdl.handle.net/10044/1/45774
DOI: https://dx.doi.org/10.1021/acsbiomaterials.7b00072
ISSN: 2373-9878
Publisher: American Chemical Society
Journal / Book Title: ACS Biomaterials Science and Engineering
Copyright Statement: © 2017 American Chemical Society
Sponsor/Funder: Medical Research Council (MRC)
Wellcome Trust
Wellcome Trust
Rosetrees Trust
Rosetrees Trust
British Skin Foundation
Diabetes Research & Wellness Foundation
Funder's Grant Number: MR/M01858X/1
109838/Z/15/Z
109838/Z/15/Z
A1071
A1071
BSF Grant No. 8030
1770
Publication Status: Published
Embargo Date: 2018-03-21
Appears in Collections:Faculty of Engineering
Bioengineering



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