AMPK signalling in health and disease

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Title: AMPK signalling in health and disease
Author(s): Carling, D
Item Type: Journal Article
Abstract: In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Activation of AMPK increases the rate of catabolic (ATP-generating) pathways and decreases the rate of anabolic (ATP-utilising) pathways. In addition to its role in maintaining intracellular energy balance, AMPK regulates whole body energy metabolism. Given its key role in controlling energy homeostasis, AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases, including type 2 diabetes and, more recently, cancer. Here I review the regulation of AMPK and its potential as a target for therapeutic intervention in human disease.
Publication Date: 21-Feb-2017
Date of Acceptance: 1-Feb-2017
ISSN: 1879-0410
Publisher: Elsevier
Start Page: 31
End Page: 37
Journal / Book Title: Current Opinion in Cell Biology
Volume: 45
Copyright Statement: © 2017 Published by Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Keywords: Developmental Biology
0601 Biochemistry And Cell Biology
Publication Status: Published
Conference Place: England
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine

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