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Plasmonic chirality imprinting on nucleobase-displaying supramolecular nanohelices by metal-nucleobase recognition

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Title: Plasmonic chirality imprinting on nucleobase-displaying supramolecular nanohelices by metal-nucleobase recognition
Authors: Lin, Y
Pashuck, ET
Thomas, MR
Amdursky, N
Wang, S-T
Chow, LW
Stevens, MM
Item Type: Journal Article
Abstract: Supramolecular self-assembly is an important process that enables the conception of complex structures mimicking biological motifs. Herein, we constructed helical fibrils through chiral self-assembly of nucleobase–peptide conjugates (NPCs), where achiral nucleobases are helically displayed on the surface of fibrils, comparable to polymerized nucleic acids. Selective binding between DNA and the NPC fibrils was observed with fluorescence polarization. Taking advantage of metal–nucleobase recognition, we highlight the possibility of deposition/assembly of plasmonic nanoparticles onto the fibrillar constructs. In this approach, the supramolecular chirality of NPCs can be adaptively imparted to metallic nanoparticles, covering them to generate structures with plasmonic chirality that exhibit significantly improved colloidal stability. The self-assembly of rationally designed NPCs into nanohelices is a promising way to engineer complex, optically diverse nucleobase-derived nanomaterials.
Issue Date: 19-Jan-2017
Date of Acceptance: 1-Jan-2017
URI: http://hdl.handle.net/10044/1/45700
DOI: https://dx.doi.org/10.1002/anie.201610976
ISSN: 1433-7851
Publisher: Wiley
Start Page: 2361
End Page: 2365
Journal / Book Title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume: 56
Issue: 9
Copyright Statement: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Y. Lin, E. T. Pashuck, M. R. Thomas, N. Amdursky, S.-T. Wang, L. W. Chow, M. M. Stevens, Angew. Chem. Int. Ed. 2017, 56, 2361., which has been published in final form at https://dx.doi.org/10.1002/anie.201610976
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Funder's Grant Number: EP/K031953/1
EP/K020641/1
ERC-2013-CoG-616417
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
biomimetic chemistry
helical structures
peptides
plasmonic chirality
self-assembly
NUCLEIC-ACIDS
DNA
GOLD
NANOFIBERS
NANOPARTICLES
AMPHIPHILES
ASSEMBLIES
NUCLEOPEPTIDES
NUCLEOSIDE
HYDROGELS
Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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