Transcription regulation and membrane stress management in enterobacterial pathogens

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Title: Transcription regulation and membrane stress management in enterobacterial pathogens
Authors: Zhang, N
Jovanovic, G
McDonald, C
Ces, O
Zhang, X
Buck, M
Item Type: Journal Article
Abstract: Transcription regulation in a temporal and conditional manner underpins the lifecycle of enterobacterial pathogens. Upon exposure to a wide array of environmental cues, these pathogens modulate their gene expression via the RNA polymerase and associated sigma factors. Different sigma factors, either involved in general 'house-keeping' or specific responses, guide the RNA polymerase to their cognate promoter DNAs. The major alternative sigma54 factor when activated helps pathogens manage stresses and proliferate in their ecological niches. In this chapter, we review the function and regulation of the sigma54-dependent Phage shock protein (Psp) system-a major stress response when Gram-negative pathogens encounter damages to their inner membranes. We discuss the recent development on mechanisms of gene regulation, signal transduction and stress mitigation in light of different biophysical and biochemical approaches.
Issue Date: 19-May-2016
Date of Acceptance: 19-May-2016
URI: http://hdl.handle.net/10044/1/45476
DOI: https;//dx.doi.org/10.1007/978-3-319-32189-9_13
ISSN: 0065-2598
Publisher: Kluwer
Start Page: 207
End Page: 230
Journal / Book Title: Advances in Experimental Medicine and Biology
Volume: 915
Copyright Statement: © 2016 Springer International Publishing Switzerland. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-32189-9_13
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Medicine, Research & Experimental
Microbiology
Life Sciences & Biomedicine - Other Topics
Research & Experimental Medicine
Transcription
RNA polymerase
Sigma factors
Psp
Membrane stress
SHOCK-PROTEIN RESPONSE
ENTERICA SEROVAR TYPHIMURIUM
ENHANCER-BINDING PROTEINS
SECRETIN-INDUCED STRESS
ESCHERICHIA-COLI-CELLS
AAA PLUS PROTEINS
PHAGE-SHOCK
RNA-POLYMERASE
YERSINIA-ENTEROCOLITICA
SIGMA-FACTOR
Bacterial Proteins
Cell Membrane
Enterobacteriaceae
Gene Expression Regulation, Bacterial
Heat-Shock Proteins
Host-Pathogen Interactions
Models, Molecular
Protein Conformation
RNA Polymerase Sigma 54
Signal Transduction
Stress, Physiological
Structure-Activity Relationship
Trans-Activators
Transcription, Genetic
General & Internal Medicine
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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