Zinc and diabetes

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Title: Zinc and diabetes
Author(s): Chabosseau, P
Rutter, GA
Item Type: Journal Article
Abstract: Zn(2+) ions are essential for the normal processing and storage of insulin and altered pancreatic insulin content is associated with all forms of diabetes mellitus. Work of the past decade has identified variants in the human SLC30A8 gene, encoding the zinc transporter ZnT8 which is expressed highly selectively on the secretory granule of pancreatic islet β and α cells, as affecting the risk of Type 2 Diabetes. Here, we review the regulation and roles of Zn(2+) ions in islet cells, the mechanisms through which SLC30A8 variants might affect glucose homeostasis and diabetes risk, and the novel technologies including recombinant targeted zinc probes and knockout mice which have been developed to explore these questions.
Publication Date: 1-Jun-2016
Date of Acceptance: 31-May-2016
URI: http://hdl.handle.net/10044/1/45298
DOI: https://dx.doi.org/10.1016/j.abb.2016.05.022
ISSN: 1096-0384
Publisher: Elsevier
Start Page: 79
End Page: 85
Journal / Book Title: Archives of Biochemistry and Biophysics
Volume: 611
Copyright Statement: © 2016 Published by Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biophysics
Insulin
Zinc
Diabetes
Beta cell
Zinc probe
Mouse
PANCREATIC BETA-CELLS
INSULIN-SECRETORY GRANULES
FREE CYTOSOLIC ZN2+
TRANSPORTER ZNT8
IN-VIVO
GLUCOSE-HOMEOSTASIS
SLC30A8 RS13266634
INTRACELLULAR ZN2+
GLUCAGON-SECRETION
GENE-EXPRESSION
Beta cell
Diabetes
Insulin
Mouse
Zinc
Zinc probe
Beta cell
Diabetes
Insulin
Mouse
Zinc
Zinc probe
Biochemistry & Molecular Biology
0601 Biochemistry And Cell Biology
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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