Increased brain-predicted ageing in treated HIV disease

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Title: Increased brain-predicted ageing in treated HIV disease
Author(s): Cole, JH
Underwood, J
Caan, MWA
De Francesco, D
Van Zoest, RA
Leech, R
Wit, FWNM
Portegies, P
Geurtsen, GJ
Schmand, BA
Schim van der Loeff, MF
Franceschi, C
Sabin, CA
Majoie, CBLM
Winston, A
Reiss, P
Sharp, DJ
Item Type: Journal Article
Abstract: Objective: To establish whether HIV disease is associated with abnormal levels of age-related brain atrophy, by estimating apparent “brain age” using neuroimaging and exploring whether these estimates related to HIV-status, age, cognitive performance and HIV-related clinical parameters. Methods: A large sample of virologically-suppressed HIV-positive adults (N = 162, aged 45-82 years) and highly-comparable HIV-negative controls (N = 105) were recruited as part of the COBRA collaboration. Using T1-MRI scans, a machine-learning model of healthy brain ageing was defined in an independent cohort (N = 2001, aged 18-90 years). Neuroimaging data from HIV-positive and HIV-negative individuals were then used to estimate brain-predicted age; then brain-predicted age difference (brain-PAD = brain-predicted brain age - chronological age) scores were calculated. Neuropsychological and clinical assessments were also carried out. Results: HIV-positive individuals had greater brain-PAD score (mean ± SD = 2.15 ± 7.79 years) compared to HIV-negative individuals (-0.87 ± 8.40 years; b = 3.48, p < 0.01). Increased brain-PAD score was associated with decreased performance in multiple cognitive domains (information processing speed, executive function, memory) and general cognitive performance across all participants. Brain-PAD score was not associated with age, duration of HIV-infection or other HIV-related measures. Conclusions: Increased apparent brain ageing, predicted using neuroimaging, was observed in HIV-positive adults, despite effective viral suppression. Furthermore, the magnitude of increased apparent brain ageing related to cognitive deficits. However, predicted brain age difference did not correlate with chronological age or duration of HIV-infection, suggesting that HIV disease may accentuate, rather than accelerate brain ageing.
Publication Date: 3-Mar-2017
Date of Acceptance: 17-Jan-2017
URI: http://hdl.handle.net/10044/1/45026
DOI: https://dx.doi.org/10.1212/WNL.0000000000003790
ISSN: 0028-3878
Publisher: American Academy of Neurology (AAN)
Start Page: 1349
End Page: 1357
Journal / Book Title: Neurology
Volume: 88
Issue: 14
Copyright Statement: © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Sponsor/Funder: Commission of the European Communities
National Institute for Health Research
Funder's Grant Number: 305522
NIRH-RP-011-048
Keywords: Neurology & Neurosurgery
1103 Clinical Sciences
1109 Neurosciences
1702 Cognitive Science
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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