Microcirculation of blood and interstitial fluid in a poroelastic model of the liver

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Title: Microcirculation of blood and interstitial fluid in a poroelastic model of the liver
Author(s): Argungu, M
Tweedy, JH
Item Type: Conference Paper
Abstract: Cirrhosis is a life-threatening condition that represents a leading cause of death in the western world. In this condition the structure of the liver tissue is altered by the development of fibrosis, which means it becomes stiffer and its permeability to blood and interstitial flow within the tissue that are vital to its function are reduced. We develop a new mathematical model based on those by Bonfiglio et al (2010) and Siggers et al (2014), which we use to investigate the changes in liver volume, blood flow and lymphatic uptake, which measures interstitial flow, that occur as the tissue becomes progressively stiffer. Our results suggest that the typical changes that develop during cirrhosis have a significant effect on the permeability properties, highlighting the seriousness of this condition.
Publication Date: 9-Jul-2017
Date of Acceptance: 17-Feb-2017
URI: http://hdl.handle.net/10044/1/44792
Publisher: ASCE
Journal / Book Title: Conference Proceedings of 6th Biot Conference on Poromechanics
Copyright Statement: This paper is embargoed until publication.
Conference Name: 6th Bio Conference on Poromechanics 2017
Publication Status: Accepted
Start Date: 2017-07-09
Finish Date: 2017-07-13
Conference Place: Paris, France
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Faculty of Engineering

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