Immunity to uropathogens: the emerging roles of inflammasomes

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Title: Immunity to uropathogens: the emerging roles of inflammasomes
Author(s): Hamilton, C
Tan, L
Miethke, T
Anand, PK
Item Type: Journal Article
Abstract: Urinary tract infections (UTIs) cause a huge burden of morbidity worldwide with recurrence of UTIs becoming significantly frequent due to the emergence of antibiotic-resistant bacterial strains. Recent research has focussed on interactions between the innate and adaptive immune responses to pathogens colonizing the urinary tract. Inflammasomes are part of the innate immune defense and respond rapidly to several infectious diseases. Assembly of the multiprotein inflammasome complex activates Caspase-1, processes proinflammatory cytokines IL-1β and IL-18, and induces pyroptosis. These effector pathways, in turn, act at different levels to either prevent or resolve infection, or eliminate the infectious agent itself. Whilst in certain instances inflammasome activation promotes tissue pathology, the precise functions of inflammasomes in UTIs remain unexplored. In this review, we discuss recent studies on the roles of inflammasomes in UTIs with a particular focus on common infections of the urinary tract. An improved understanding of inflammasomes may provide valuable novel approaches for the design of diagnostics and therapeutics for complicated UTIs, thus enabling us to counteract the challenge of drug resistance.
Publication Date: 7-Mar-2017
Date of Acceptance: 9-Feb-2017
URI: http://hdl.handle.net/10044/1/44656
DOI: https://dx.doi.org/10.1038/nrurol.2017.25
ISSN: 1759-4812
Publisher: Nature Publishing Group
Journal / Book Title: Nature Reviews Urology
Copyright Statement: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Sponsor/Funder: The Royal Society
Wellcome Trust
Funder's Grant Number: N/A
N/A
Keywords: 1103 Clinical Sciences
Publication Status: Accepted
Appears in Collections:Department of Medicine
Faculty of Medicine



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