Studies in pre-existing heart disease and pregnancy

File Description SizeFormat 
Curry-R-2016-PhD-Thesis.pdfThesis1.76 MBAdobe PDFView/Open
Title: Studies in pre-existing heart disease and pregnancy
Authors: Curry, Ruth
Item Type: Thesis or dissertation
Abstract: Aims: To study the effect of pre-existing maternal cardiac disease on cardiovascular function during pregnancy, and on obstetric and fetal/neonatal outcomes, and to investigate maternal risk factors for adverse events. Methods: Retrospective case note review. Results: Four hundred and eighty-nine pregnancies in 326 women were studied. Most pregnancies (50%) occurred in women with congenital heart disease. There were 4 maternal deaths, 6 stillbirths and 5 neonatal deaths. Cardiovascular events occurred in 7.4% of pregnancies, while obstetric and perinatal complications occurred in 34% and 30% of pregnancies respectively. Conclusions: Pregnancy in women with pre-existing heart disease continues to be associated with high rates of maternal and neonatal mortality and morbidity. This work highlights the importance of effective prepregnancy counselling and meticulous surveillance during pregnancy, delivery and the puerperium by an experienced multidisciplinary team. Additionally there is an urgent need for well-designed randomisedcontrolled trials to determine best practice.
Content Version: Open Access
Issue Date: Sep-2014
Date Awarded: Mar-2016
URI: http://hdl.handle.net/10044/1/44495
Supervisor: Johnson, Mark
Department: Department of Surgery & Cancer
Publisher: Imperial College London
Qualification Level: Doctoral
Qualification Name: Doctor of Medicine (Research) MD (Res)
Appears in Collections:Medicine PhD theses



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx