Morbidity and mortality due to Bordetella pertussis: a significant pathogen in West Africa?

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Title: Morbidity and mortality due to Bordetella pertussis: a significant pathogen in West Africa?
Author(s): Kampmann, B
Mackenzie, G
Item Type: Journal Article
Abstract: In the absence of specific surveillance platforms for pertussis and availability of suitable diagnostics at the hospital level, reliable data that describe morbidity and mortality from pertussis are difficult to obtain in any setting, as is the case in West Africa. Here, we summarize the available evidence of the burden of pertussis in the region, given historical data, and describe recent and ongoing epidemiological studies that offer opportunities for additional data collection. The available seroepidemiological data provide evidence of ongoing circulation of Bordetella pertussis in the region. Due to the lack of systematic and targeted surveillance with laboratory confirmation of B. pertussis infection, we cannot definitively conclude that pertussis disease is well controlled in West Africa. However, based on observations by clinicians and ongoing demographic surveillance systems that capture morbidity and mortality data in general terms, currently there is no evidence that pertussis causes a significant burden of disease in young children in West Africa.
Publication Date: 2-Nov-2016
Date of Acceptance: 1-Nov-2016
URI: http://hdl.handle.net/10044/1/44485
DOI: https://dx.doi.org/10.1093/cid/ciw560
ISSN: 1537-6591
Publisher: Oxford University Press (OUP)
Start Page: S142
End Page: S147
Journal / Book Title: Clinical Infectious Diseases
Volume: 63
Issue: suppl_4
Copyright Statement: © 2016 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciw560
Copyright Statement: © 2016 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciw560
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
pertussis
West Africa
surveillance
case finding
VACCINATION PROGRAM
INFECTION
SEROPREVALENCE
EPIDEMIOLOGY
DIAGNOSIS
ANTITOXIN
CHILDREN
GAMBIA
West Africa
case finding
pertussis
surveillance
Microbiology
06 Biological Sciences
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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