A compact synchronous cellular model of nonlinear calcium dynamics: simulation and FPGA synthesis results

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Title: A compact synchronous cellular model of nonlinear calcium dynamics: simulation and FPGA synthesis results
Author(s): Soleimani, H
Drakakis, EM
Item Type: Journal Article
Abstract: Recent studies have demonstrated that calcium is a widespread intracellular ion that controls a wide range of temporal dynamics in the mammalian body. The simulation and validation of such studies us- ing experimental data would bene t from a fast large scale simulation and modelling tool. This paper presents a compact and fully recon gurable cellular calcium model capable of mimicking Hopf bifurcation phenomenon and various nonlinear responses of the biological calcium dynamics. The proposed cellular model is synthesized on a digital platform for a single unit and a network model. Hardware synthesis, physical implementation on FPGA, and theoretical analysis con rm that the proposed cellular model can mimic the biological calcium behaviors with considerably low hardware overhead. The approach has the potential to speed up large{scale simulations of slow intracellular dynamics by sharing more cellular units in real{time. To this end, various networks constructed by pipelining 10k to 40k cellular calcium units are compared with an equivalent simulation run on a standard PC workstation. Results show that the cellular hardware model is, on average, 83 times faster than the CPU version.
Publication Date: 23-May-2017
Date of Acceptance: 28-Nov-2016
URI: http://hdl.handle.net/10044/1/44423
DOI: https://dx.doi.org/10.1109/TBCAS.2016.2636183
ISSN: 1932-4545
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Start Page: 703
End Page: 713
Journal / Book Title: IEEE Transactions on Biomedical Circuits and Systems
Volume: 11
Issue: 3
Copyright Statement: © 2016 EU. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Keywords: Science & Technology
Engineering, Biomedical
Engineering, Electrical & Electronic
Calcium induced calcium releasedmodel (CICR)
field programable gate array (FPGA)
synchronous cellular calcium model
Electrical & Electronic Engineering
0903 Biomedical Engineering
0906 Electrical And Electronic Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering

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