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pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure

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Title: pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure
Authors: McNamee, J
Gillies, M
Barrett, N
Agus, A
Beale, R
Bentley, A
Bodenham, A
Brett, S
Brodie, D
Finney, S
Gordon, A
Griffiths, M
Harrison, D
Jackson, C
McDowell, C
McNally, C
Perkins, G
Tunnicliffe, W
Vuylsteke, A
Walsh, T
Wise, M
Young, D
McAuley, D
Item Type: Journal Article
Abstract: One of the few interventions to demonstrate improved outcomes for acute hypoxaemic respiratory failure is reducing tidal volumes when using mechanical ventilation, often termed lung protective ventilation. Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2R) can facilitate reducing tidal volumes. pRotective vEntilation with veno-venouS lung assisT (REST) is a randomised, allocation concealed, controlled, open, multicentre pragmatic trial to determine the clinical and cost-effectiveness of lower tidal volume mechanical ventilation facilitated by vv-ECCO2R in patients with acute hypoxaemic respiratory failure. Patients requiring intubation and mechanical ventilation for acute hypoxaemic respiratory failure will be randomly allocated to receive either vv-ECCO2R and lower tidal volume mechanical ventilation or standard care with stratification by recruitment centre. There is a need for a large randomised controlled trial to establish whether vv-ECCO2R in acute hypoxaemic respiratory failure can allow the use of a more protective lung ventilation strategy and is associated with improved patient outcomes.
Issue Date: 19-Dec-2016
Date of Acceptance: 16-Oct-2016
URI: http://hdl.handle.net/10044/1/44406
DOI: https://dx.doi.org/10.1177/1751143716681035
ISSN: 1751-1437
Publisher: Sage Publications
Start Page: 159
End Page: 169
Journal / Book Title: Journal of the Intensive Care Society
Volume: 18
Issue: 2
Copyright Statement: © The Intensive Care Society 2016.
Sponsor/Funder: The Intensive Care Foundation
Intensive Care Society
Funder's Grant Number: Deputy Director of Research
Co-Director of Research
Publication Status: Published
Open Access location: http://journals.sagepub.com/doi/full/10.1177/1751143716681035
Appears in Collections:Division of Surgery
Faculty of Medicine



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