Susceptibility weighted imaging to detect nigral iron accumulation in Parkinson's disease

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Title: Susceptibility weighted imaging to detect nigral iron accumulation in Parkinson's disease
Authors: Martin-Bastida, A
Politis, M
Loane, C
Lao-Kaim, N
Valle-Guzman, N
Kefalopoulou, Z
Gesine, P
Foltynie, T
Barker, R
Piccini, P
Item Type: Conference Paper
Abstract: Introduction: Dopaminergic neuron loss in substantia nigra (SN) in patients with PD is associated with deposits of iron. Susceptibility weighted imaging (SWI) is a high-resolution MR-based imaging technique for quantifying iron depositions in vivo. SWI may be a robust biomarker for clinical characterization of PD. Methods: Forty-two patients with PD were studied with SWI imaging. Average phase shift (radians) and percentage iron deposition of the SN were analysed using SPIN software. SWI data were also compared between PD patients with early (4.0±0.5 PD duration) vs. established PD (7.7±1.9), and according to low (21.2±4.5) vs. high (41.3±8.7) UPDRS-III-assessed motor symptoms severity. Data were interrogated using analysis of covariance (age), relative to healthy controls, and using post hoc univariate tests. Results: PD patients had higher phase shift values (p<0.01) and iron deposition percentage (p<0.001) in the SN bilaterally, compared to healthy controls. Phase shift values were significantly higher in patients with established PD compared to those with early PD (p<0.05) and higher UPDRS-III motor scores (p<0.05). Conclusions: PD patients show higher levels of deposits of iron in SN compared to healthy controls, and increased iron levels in SN are associated with prolonged disease and increased motor disability
Issue Date: 14-Oct-2015
Date of Acceptance: 10-Sep-2015
URI: http://hdl.handle.net/10044/1/44325
DOI: https://dx.doi.org/10.1136/jnnp-2015-312379.180
ISSN: 0022-3050
Publisher: BMJ PUBLISHING GROUP
Start Page: 49
End Page: 49
Journal / Book Title: Journal of Neurology, Neurosurgery and Psychiatry
Volume: 86
Issue: 11
Copyright Statement: © 2015 The Author(s). This article has been accepted for publication in Journal of Neurology, Neurosurgery and Psychiatry following peer review. The definitive copyedited, typeset version Martin-Bastida A, Politis M, Loane C, et al SUSCEPTIBILITY WEIGHTED IMAGING TO DETECT NIGRAL IRON ACCUMULATION IN PARKINSON'S DISEASE J Neurol Neurosurg Psychiatry 2015;86:e4 is available online at: https://dx.doi.org/10.1136/jnnp-2015-312379.180
Sponsor/Funder: Parkinson's UK
Funder's Grant Number: PaMIR-RB4811 / J-1204
Conference Name: Annual Meeting of the Association-of-British-Neurologists (ABN)
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Psychiatry
Surgery
Neurosciences & Neurology
Neurology & Neurosurgery
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Start Date: 2015-09-10
Conference Place: London, ENGLAND
Appears in Collections:Department of Medicine
Faculty of Medicine



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