Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

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Title: Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer
Authors: Thompson, A
Manning, H
Brydegaard, M
Coda, S
Kennedy, G
Patalay, R
Waitong-Braemming, U
De Beule, P
Neil, M
Andersson-Engels, S
Itoh, Y
Bendsøe, N
Dunsby, C
Svanberg, K
French, PM
Item Type: Conference Paper
Abstract: We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.
Editors: Alfano, RR
Issue Date: 22-Jan-2011
Date of Acceptance: 1-Jan-2011
URI: http://hdl.handle.net/10044/1/44020
DOI: https://dx.doi.org/10.1117/12.875120
ISBN: 9780819484321
ISSN: 1996-756X
Publisher: Society of Photo-optical Instrumentation Engineers (SPIE)
Journal / Book Title: Proceedings of SPIE
Volume: 7895
Copyright Statement: © 2011 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/F040202/1
Conference Name: SPIE Photonics West 2011
Keywords: Science & Technology
Technology
Physical Sciences
Engineering, Biomedical
Optics
Engineering
fluorescence
fluorescence lifetime
diffuse reflectance
osteoarthritis
skin cancer
spectrometer
fibre probe
ELASTIN
CARCINOMA
MELANOMAS
COLLAGEN
Publication Status: Published
Start Date: 2011-01-22
Finish Date: 2011-01-27
Conference Place: Moscone Center, San Francisco, California, USA
Appears in Collections:Faculty of Engineering
Physics
Computing
Photonics
Faculty of Medicine
Faculty of Natural Sciences



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