Biomechanical properties of Bovine tendon xenografts treated with a modern processing method

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Title: Biomechanical properties of Bovine tendon xenografts treated with a modern processing method
Author(s): Colaco, H
Lord, BR
Back, DL
Davies, AJ
Amis, AA
Ajuied, A
Item Type: Journal Article
Abstract: Xenograft tendons have been used in few human studies, with variable results. With the advent of novel tissue processing techniques, which may mitigate against an immune - mediated rejection response without adversely affecting mech anical properties, there may now be a clinical role for xenograft tendons, particularly in knee ligament reconstruction. We hypothesize that ‘BioCleanse® ’ processed bovine extensor digitorum m edialis (EDM) tendons exhibit favorable time - zero pre - implantati on biomechanical characteristics when compared to both unprocessed bovine EDM tendons and BioCleanse® processed human cadaveric allograft tibialis anterior tendons. In this in vitro case controlled laboratory study, three groups of tendons underwent a 5 - stage static loading test protocol: 15 BioCleanse® bovine (BCB), 15 fresh frozen unprocessed bovine (FFB), and 12 BioCleanse® human allograft (BCA) tendons. Cross - sectional area of th e grafts was measured using an alginate molding technique, and tendons were mounted within an Instron® 5565 Materials Testing System using cryogenic clamps. BCB tendons displayed a higher ultimate tensile stress (p<0.05) , with equivalent ultimate failure load, creep, and modulus of elasticity when compared to the FFB tendons (p > 0.05). BCB tendons had an equivalent cross - sectional area to the BCA tendons (p>0.05) whilst exhibiting a greater failure load, ultimate tensile stre ss , less creep and a higher modu lus of elasticity (p<0.05). The BioCleanse® process d id not adversely affect the time - zero biomechanical roperties of bovine xenograft EDM tendons. BioCleanse® processed bovine xenograft EDM tendons exhibit ed superior biomechanical characteristics when 3 co mpared with BioCleanse® processed allograft tibialis anterior tendons. These findings support further investigation of xenograft tendons in orthopaedic soft tissue reconstructive surgery.
Publication Date: 28-Feb-2017
Date of Acceptance: 11-Jan-2017
URI: http://hdl.handle.net/10044/1/43976
DOI: https://dx.doi.org/10.1016/j.jbiomech.2017.01.011
ISSN: 1873-2380
Publisher: Elsevier
Start Page: 144
End Page: 147
Journal / Book Title: Journal of Biomechanics
Volume: 53
Copyright Statement: © 2017, Elsevier. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Technology
Biophysics
Engineering, Biomedical
Engineering
Knee ligaments
Xenograft
Sterilization
Biomechanics of tendon
ANTERIOR CRUCIATE LIGAMENT
MUSCULOSKELETAL-TISSUE ALLOGRAFTS
HUMAN-IMMUNODEFICIENCY-VIRUS
MEDIAL COLLATERAL LIGAMENT
ROTATOR CUFF TEARS
MECHANICAL-PROPERTIES
TENSILE PROPERTIES
GAMMA-IRRADIATION
BONE ALLOGRAFTS
GAL ANTIBODY
Biomechanics of tendon
Knee ligaments
Sterilization
Xenograft
Biomedical Engineering
0903 Biomedical Engineering
1106 Human Movement And Sports Science
0913 Mechanical Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Mechanical Engineering



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