Mediterranean Diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

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Title: Mediterranean Diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort
Author(s): Molina-Montes, E
Sánchez, M
Buckland, G
Bueno-de-Mesquita, B
Weiderpass, E
Amiano, P
Wark, PA
Kuhn, T
Katzke, V
Huerta, JM
Ardanaz, E
Ramón Quirós, J
Affret, A
His, M
Boutron- Ruault, M
Peeters, PH
Ye, W
Sund, M
Boeing, H
Iqbal, K
Ohlsson, B
Sonestedt, E
Tjonneland, A
Petersen, KEN
Travis, RC
Skeie, G
Agnoli, C
Agnoli, C
Panico, S
Palli, D
Tumino, R
Sacerdote, C
Freisling, H
Huybrechts, I
Overvad, K
Trichopoulou, A
Bamia, C
Vasilopoulou, E
Wareham, N
Khaw, K
Cross, AJ
Ward, HA
Riboli, E
Duell, EJ
Item Type: Journal Article
Abstract: Background: The Mediterranean Diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods : Over half a million participants from 10 European countries were followed- up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol -related harmful effects . Cox proportional hazards regression models , stratified by age, sex and center, and adjusted for energy intake, body mass index (BMI) , smoking status, alcohol intake and diabetes status at recruitment , were used to estimate hazard ratio s (HR s) associated with pancreatic cancer and their corresponding 95% confidence interval s 16 (CI s) . Results: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high versus low adherence = 0.99 ; 95% CI: 0.77- 1.26, and HR per increments of 2 units in adherence to arMED = 1.00; 95% CI: 0.94- 1.06). There was no convincing evidence for heterogeneity by smoking status , BMI , diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake , or other definitions of the MD pattern. Conclusion: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC s tudy.
Publication Date: 7-Feb-2017
Date of Acceptance: 9-Jan-2017
URI: http://hdl.handle.net/10044/1/43955
DOI: https://dx.doi.org/10.1038/bjc.2017.14
ISSN: 1532-1827
Publisher: Cancer Research UK
Start Page: 811
End Page: 820
Journal / Book Title: British Journal of Cancer
Volume: 116
Copyright Statement: © 2017 Cancer Research UK. All rights reserved
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
P47328
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Mediterranean diet
pancreatic cancer
cohort study
EPIC COHORT
BREAST-CANCER
ADHERENCE
PATTERNS
METAANALYSIS
CONSUMPTION
PARTICIPANTS
POPULATION
MORTALITY
COUNTRIES
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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