Erratum to: Appearances of screen-detected versus symptomatic colorectal cancers at CT colonography

Title: Erratum to: Appearances of screen-detected versus symptomatic colorectal cancers at CT colonography
Authors: Plumb, AA
Pathiraja, F
Nickerson, C
Wooldrage, K
Burling, D
Taylor, SA
Atkin, WS
Halligan, S
Item Type: Journal Article
Abstract: OBJECTIVES: The aim of this study was to compare the morphology, radiological stage, conspicuity, and computer-assisted detection (CAD) characteristics of colorectal cancers (CRC) detected by computed tomographic colonography (CTC) in screening and symptomatic populations. METHODS: Two radiologists independently analyzed CTC images from 133 patients diagnosed with CRC in (a) two randomized trials of symptomatic patients (35 patients with 36 tumours) and (b) a screening program using fecal occult blood testing (FOBt; 98 patients with 100 tumours), measuring tumour length, volume, morphology, radiological stage, and subjective conspicuity. A commercial CAD package was applied to both datasets. We compared CTC characteristics between screening and symptomatic populations with multivariable regression. RESULTS: Screen-detected CRC were significantly smaller (mean 3.0 vs 4.3 cm, p < 0.001), of lower volume (median 9.1 vs 23.2 cm(3), p < 0.001) and more frequently polypoid (34/100, 34 % vs. 5/36, 13.9 %, p = 0.02) than symptomatic CRC. They were of earlier stage than symptomatic tumours (OR = 0.17, 95 %CI 0.07-0.41, p < 0.001), and were judged as significantly less conspicuous (mean conspicuity 54.1/100 vs. 72.8/100, p < 0.001). CAD detection was significantly lower for screen-detected (77.4 %; 95 %CI 67.9-84.7 %) than symptomatic CRC (96.9 %; 95 %CI 83.8-99.4 %, p = 0.02). CONCLUSIONS: Screen-detected CRC are significantly smaller, more frequently polypoid, subjectively less conspicuous, and less likely to be identified by CAD than those in symptomatic patients. KEY POINTS: • Screen-detected colorectal cancers (CRC) are significantly smaller than symptomatic CRC. • Screening cases are significantly less conspicuous to radiologists than symptomatic tumours. • Screen-detected CRC have different morphology compared to symptomatic tumours (more polypoid, fewer annular). • A commercial computer-aided detection (CAD) system was significantly less likely to note screen-detected CRC.
Issue Date: 17-May-2016
Date of Acceptance: 18-Feb-2016
ISSN: 1432-1084
Publisher: Springer Verlag
Start Page: 4323
End Page: 4324
Journal / Book Title: European Radiology
Volume: 26
Issue: 12
Copyright Statement: © 2016, European Society of Radiology. Owing to an oversight in typesetting, Fig. 2 was duplicated and Fig. 3 (below) omitted from the original publication. The mistake has since been corrected. The publisher apologises for this error and the inconvenience caused. The original article can by found in Spiral at:
Sponsor/Funder: Cancer Research UK
Funder's Grant Number: C8171/A16894
Keywords: Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
Nuclear Medicine & Medical Imaging
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Division of Surgery
Faculty of Medicine

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