Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

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Title: Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
Author(s): Bowtell, DD
Boehm, S
Ahmed, AA
Aspuria, P-J
Bast, RC
Beral, V
Berek, JS
Birrer, MJ
Blagden, S
Bookman, MA
Brenton, JD
Chiappinelli, KB
Martins, FC
Coukos, G
Drapkin, R
Edmondson, R
Fotopoulou, C
Gabra, H
Galon, J
Gourley, C
Heong, V
Huntsman, DG
Iwanicki, M
Karlan, BY
Kaye, A
Lengyel, E
Levine, DA
Lu, KH
McNeish, IA
Menon, U
Narod, SA
Nelson, BH
Nephew, KP
Pharoah, P
Powell, DJ
Ramos, P
Romero, IL
Scott, CL
Sood, AK
Stronach, EA
Balkwill, FR
Item Type: Journal Article
Abstract: High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.
Publication Date: 23-Oct-2015
Date of Acceptance: 1-Oct-2015
URI: http://hdl.handle.net/10044/1/43637
DOI: https://dx.doi.org/10.1038/nrc4019
ISSN: 1474-175X
Publisher: Nature Publishing Group
Start Page: 668
End Page: 679
Journal / Book Title: Nature Reviews Cancer
Volume: 15
Copyright Statement: © 2015 Macmillan Publishers Limited. All rights reserved
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
BRCA MUTATION CARRIERS
TUBAL-INTRAEPITHELIAL-CARCINOMA
OLAPARIB MAINTENANCE THERAPY
SINGLE-THRESHOLD RULE
HUMAN BREAST-TUMORS
CELL LUNG-CANCER
FALLOPIAN-TUBE
T-CELLS
GERMLINE MUTATIONS
SOMATIC MUTATIONS
Cystadenocarcinoma, Serous
Female
Humans
Neoplasm Grading
Ovarian Neoplasms
Prognosis
Survival Rate
Humans
Cystadenocarcinoma, Serous
Ovarian Neoplasms
Prognosis
Survival Rate
Female
Neoplasm Grading
Oncology & Carcinogenesis
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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