The next steps in improving the outcomes of advanced ovarian cancer

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Title: The next steps in improving the outcomes of advanced ovarian cancer
Author(s): Openshaw, MR
Fotopoulou, C
Blagden, S
Gabra, H
Item Type: Journal Article
Abstract: Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication. Second, acquisition of chemotherapy resistance results in untreatable progressive disease. Advances in treatment of advanced ovarian cancer involve a spectrum of interventions including improvements in frontline debulking surgery and combination chemotherapy. Anti-angiogenic factors have been shown to have activity in frontline and recurrent disease while novel chemotherapeutic agents and targeted treatments are in development particularly for disease that is resistant to platinum-based chemotherapy. These developments aim to improve the progression-free and overall survival of women with advanced ovarian cancer.
Publication Date: 1-Jun-2015
Date of Acceptance: 1-Jun-2015
URI: http://hdl.handle.net/10044/1/43615
DOI: http://dx.doi.org/10.2217/whe.15.6
ISSN: 1745-5057
Publisher: Future Medicine
Start Page: 355
End Page: 367
Journal / Book Title: Women's Health
Volume: 11
Issue: 3
Copyright Statement: The final, definitive version of this paper has been published in Women's Health, Vol.11, Issue 3, June 2015 by Sage Publications Ltd, All rights reserved. © SAGE Publications Ltd, 2015. It is available at: http://online.sagepub.com/.
Keywords: BRCA
PARP inhibitors
TP53
adjuvant chemotherapy
debulking surgery
immunotherapy
intraperitoneal chemotherapy
neoadjuvant chemotherapy
ovarian cancer
platinum resistance
Antineoplastic Combined Chemotherapy Protocols
Combined Modality Therapy
Female
Global Health
Gynecologic Surgical Procedures
Humans
Neoadjuvant Therapy
Ovarian Neoplasms
Randomized Controlled Trials as Topic
Women's Health
Humans
Ovarian Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Combined Modality Therapy
Neoadjuvant Therapy
Gynecologic Surgical Procedures
Women's Health
Female
Randomized Controlled Trials as Topic
Global Health
Obstetrics & Reproductive Medicine
1114 Paediatrics And Reproductive Medicine
1117 Public Health And Health Services
Publication Status: Published
Conference Place: United States
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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