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Biomaterials: a potential pathway to healing chronic wounds?

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Title: Biomaterials: a potential pathway to healing chronic wounds?
Authors: Pop, MA
Almquist, BD
Item Type: Journal Article
Abstract: Chronic dermal wounds are a devastating problem that disproportionally affect individuals with conditions such as diabetes, paralysis, or simply old age. These wounds are extremely challenging to treat due to a heterogeneous combination of causative factors, creating a substantial burden on healthcare systems worldwide. Despite their large impact, there is currently a startling lack of options for effectively treating the underlying biological changes that occur within the wounds. Biomaterials possess an enticing ability to provide new comprehensive approaches to healing these devastating wounds; advanced wound dressings are now being developed that enable the ability to coordinate temporal delivery of multiple therapeutics, protect sensitive biologics from degradation, and provide supportive matrices that encourage the growth of tissue. This positions biomaterials as a potential ‘conductor’ of wound repair, allowing them to simultaneously address numerous barriers to healing, and in turn providing a promising pathway to innovative new technologies for driving successful healing.
Issue Date: 17-Jan-2017
Date of Acceptance: 28-Dec-2016
URI: http://hdl.handle.net/10044/1/43596
DOI: https://dx.doi.org/10.1111/exd.13290
ISSN: 1600-0625
Publisher: Wiley
Start Page: 760
End Page: 763
Journal / Book Title: Experimental Dermatology
Volume: 26
Issue: 9
Copyright Statement: © 2017 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Royal Society
Wellcome Trust
Wellcome Trust
Rosetrees Trust
Rosetrees Trust
Diabetes Research & Wellness Foundation
Funder's Grant Number: RG140614
109838/Z/15/Z
109838/Z/15/Z
A1071
A1071
1770
Keywords: Science & Technology
Life Sciences & Biomedicine
Dermatology
biomaterials
chronic wound
diabetic ulcer
tissue repair
wound healing
SKIN REGENERATION
IN-VIVO
1103 Clinical Sciences
Dermatology & Venereal Diseases
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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