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Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma

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Title: Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma
Authors: Chandrawati, R
Chang, J
Reina-Torres, E
Jumeaux, C
Sherwood, JM
Stamer, WD
Zelikin, AN
Overby, DR
Stevens, MM
Item Type: Journal Article
Abstract: Nitric oxide (NO) has been shown to lower intraocular pressure (IOP), however its therapeutic effects on outflow physiology are location- and dose-dependent. Here, a NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in mouse model.
Issue Date: 21-Feb-2017
Date of Acceptance: 28-Dec-2016
URI: http://hdl.handle.net/10044/1/43593
DOI: https://dx.doi.org/10.1002/adma.201604932
ISSN: 1521-4095
Publisher: Wiley
Journal / Book Title: Advanced Materials
Volume: 29
Issue: 16
Copyright Statement: © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Commission of the European Communities
Wellcome Trust
Commission of the European Communities
Funder's Grant Number: PIIF-GA-2011-299936
098411/Z/12/Z
ERC-2013-CoG-616417
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
OPEN-ANGLE GLAUCOMA
HUMAN TRABECULAR MESHWORK
AQUEOUS-HUMOR OUTFLOW
LATANOPROSTENE BUNOD 0.024-PERCENT
TIMOLOL MALEATE 0.5-PERCENT
SOLUBLE GUANYLATE-CYCLASE
INTRAOCULAR-PRESSURE
OCULAR HYPERTENSION
DRUG-DELIVERY
CILIARY MUSCLE
glaucoma
layer-by-layer capsules
liposomes
nitric oxide
β-galactosidase
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Publication Status: Published
Article Number: 1604932
Appears in Collections:Faculty of Engineering
Materials
Bioengineering
Faculty of Natural Sciences



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