Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort

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Title: Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort
Authors: Matejcic, M
De Batlle, J
Ricci, C
Biessy, C
Perrier, F
Huybrechts, I
Weiderpass, E
Ruault, BM
Cadeau, C
His, M
Cox, DG
Boeing, H
Fortner, RT
Kaaks, R
Lagiou, P
Trichopoulou, A
Benetou, V
Tumino, R
Panico, S
Sieri, S
Palli, D
Ricceri, F
Bueno-de-Mesquita, HB
Skeie, G
Amiano, P
Sánchez, MJ
Chirlaque, MD
Barricarte, A
Quirós, JR
Buckland, G
Van Gils, CH
Peeters, PH
Key, TJ
Riboli, E
Gylling, B
Zeleniuch-Jacquotte, A
Gunter, MJ
Romieu, I
Chajès, V
Item Type: Journal Article
Abstract: Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (ER, PR, and HER2), alcohol intake, and MTHFR polymorphisms (677C>T and 1298A>C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.26; 95% CI 1.00-1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.29; 95% CI 1.02-1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.
Issue Date: 1-Dec-2016
Date of Acceptance: 18-Oct-2016
ISSN: 1097-0215
Publisher: Wiley: 12 months
Start Page: 1246
End Page: 1259
Journal / Book Title: International Journal of Cancer
Volume: 140
Issue: 6
Copyright Statement: © 2016 UICC. This is the accepted version of the following article, which has been published in final form at
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
Keywords: MTHFR polymorphism
breast cancer
hormone receptor status
plasma biomarkers
vitamin B12
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Conference Place: United States
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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