Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis

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Title: Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis
Authors: Seddon, JA
Schaaf, HS
Item Type: Journal Article
Abstract: Over the last 10 years, interest in pediatric tuberculosis (TB) has increased dramatically, together with increased funding and research. We have a better understanding of the burden of childhood TB as well as a better idea of how to diagnose it. Our appreciation of pathophysiology is improved and with it investigators are beginning to consider pediatric TB as a heterogeneous entity, with different types and severity of disease being treated in different ways. There have been advances in how to treat both TB infection and TB disease caused by both drug-susceptible as well as drug-resistant organisms. Two completely novel drugs, bedaquiline and delamanid, have been developed, in addition to the use of older drugs that have been re-purposed. New regimens are being evaluated that have the potential to shorten treatment. Many of these drugs and regimens have first been investigated in adults with children an afterthought, but increasingly children are being considered at the outset and, in some instances studies are only conducted in children where pediatric-specific issues exist.
Issue Date: 24-Nov-2016
Date of Acceptance: 3-Nov-2016
ISSN: 2200-6133
Publisher: BioMed Central
Journal / Book Title: Pneumonia
Volume: 8
Issue: 20
Copyright Statement: © 2016 The Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine

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