Hepatitis C treatment: where are we now?

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Title: Hepatitis C treatment: where are we now?
Author(s): Burstow, N
Mohamed, Z
Gomaa, AI
Sonderup, MW
Cook, NA
Waked, I
Spearman, CW
Taylor-Robinson, S
Item Type: Journal Article
Abstract: Chronic hepatitis C infection affects millions of people worldwide and confers significant morbidity and mortality. Effective treatment is needed to prevent disease progression and associated complications. Previous treatment options were limited to interferon and ribavirin regimens, which gave low cure rates and were associated with unpleasant side effects. The era of direct acting antiviral (DAA) therapies began with the development of the first-generation of NS3/4A protease inhibitors (PI) in 2011. They vastly improved outcomes for patients, particularly those with genotype 1 infection, the most prevalent genotype globally. Since then a multitude of DAAs have been licensed for use and outcomes for patients have improved further, with fewer side effects and cure rates approaching 100%. Recent regimens are interferon-free, and in many cases, ribavirin-free and involve a combination of DAA agents. This review summarises the treatment options currently available and discusses potential barriers that may delay the global eradication of hepatitis C.
Publication Date: 31-Dec-2017
Date of Acceptance: 19-Dec-2016
URI: http://hdl.handle.net/10044/1/43275
ISSN: 1178-7074
Publisher: Dove Medical Press
Journal / Book Title: International Journal of General Medicine
Copyright Statement: This paper is embargoed until publication. Once published will be available fully open access.
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Wellcome Trust
Wellcome Trust
Funder's Grant Number: 097816/Z/11/ZR
097816/Z/11/A
097816/Z/11/B
105603/Z/14/Z
Keywords: 1103 Clinical Sciences
Publication Status: Accepted
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Division of Surgery
Faculty of Medicine



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