A combined X-ray scattering and simulation study of halothane in membranes at raised pressures

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Title: A combined X-ray scattering and simulation study of halothane in membranes at raised pressures
Author(s): McCarthy, NL
Brooks, NJ
Tyler, AII
ElGamacy, M
Welche, P
Payne, MC
Chau, PL
Item Type: Journal Article
Abstract: Using a combination of high pressure wide angle X-ray scattering exper- iments and molecular dynamics simulations, we probe the e ect of the archetypal general anaesthetic halothane on the lipid hydrocarbon chain packing and ordering in model bilayers and the variation in these parame- ters with pressure. Incorporation of halothane into the membrane causes an expansion of the lipid hydrocarbon chain packing at all pressures but the e ect of halothane incorporation on the hydrocarbon chain order parameter is signi cantly reduced at elevated pressure.
Publication Date: 4-Jan-2017
Date of Acceptance: 16-Dec-2016
URI: http://hdl.handle.net/10044/1/43270
DOI: https://dx.doi.org/10.1016/j.cplett.2016.12.041
ISSN: 0009-2614
Publisher: Elsevier
Start Page: 21
End Page: 27
Journal / Book Title: Chemical Physics Letters
Volume: 671
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/J017566/1
Copyright Statement: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
Keywords: Chemical Physics
02 Physical Sciences
03 Chemical Sciences
10 Technology
Publication Status: Published
Open Access location: http://www.sciencedirect.com/science/article/pii/S000926141630999X
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences



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