Morphometric model for discrimination between glioblastoma multiforme and solitary metastasis using three-dimensional shape analysis

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Title: Morphometric model for discrimination between glioblastoma multiforme and solitary metastasis using three-dimensional shape analysis
Authors: Yang, G
Jones, TL
Howe, FA
Barrick, TR
Item Type: Journal Article
Abstract: Purpose: Glioblastoma multiforme (GBM) and brain metastasis (MET) are the most common intra-axial brain neoplasms in adults and often pose a diagnostic dilemma using standard clinical MRI. These tumor types require different oncological and surgical management, which subsequently influence prognosis and clinical outcome. Methods: Here, we hypothesize that GBM and MET possess different three-dimensional (3D) morphological attributes based on their physical characteristics. A 3D morphological analysis was applied on the tumor surface defined by our diffusion tensor imaging (DTI) segmentation technique. It segments the DTI data into clusters representing different isotropic and anisotropic water diffusion characteristics, from which a distinct surface boundary between healthy and pathological tissue was identified. Morphometric features of shape index and curvedness were then computed for each tumor surface and used to build a morphometric model of GBM and MET pathology with the goal of developing a tumor classification method based on shape characteristics. Results: Our 3D morphometric method was applied on 48 untreated brain tumor patients. Cross-validation resulted in a 95.8% accuracy classification with only two shape features needed and that can be objectively derived from quantitative imaging methods. Conclusion: The proposed 3D morphometric analysis framework can be applied to distinguish GBMs from solitary METs.
Issue Date: 14-Jul-2015
Date of Acceptance: 23-Jun-2015
URI: http://hdl.handle.net/10044/1/43256
DOI: https://dx.doi.org/10.1002/mrm.25845
ISSN: 0740-3194
Publisher: Wiley
Start Page: 2505
End Page: 2516
Journal / Book Title: Magnetic Resonance in Medicine
Volume: 75
Issue: 6
Copyright Statement: © 2015 Wiley Periodicals, Inc. This is the accepted version of the following article: ang, G., Jones, T. L., Howe, F. A. and Barrick, T. R. (2016), Morphometric model for discrimination between glioblastoma multiforme and solitary metastasis using three-dimensional shape analysis. Magn. Reson. Med, 75: 2505–2516. doi:10.1002/mrm.25845, which has been published in final form at https://dx.doi.org/10.1002/mrm.25845
Keywords: Nuclear Medicine & Medical Imaging
0903 Biomedical Engineering
Publication Status: Published
Open Access location: http://dx.doi.org/10.1002/mrm.25845
Appears in Collections:National Heart and Lung Institute



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