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Dietary flavonoid intake & colorectal cancer risk in the European prospective investigation into cancer & nutrition (EPIC) Cohort

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Title: Dietary flavonoid intake & colorectal cancer risk in the European prospective investigation into cancer & nutrition (EPIC) Cohort
Authors: Zamoros-Ros, R
Barupal, DK
Rothwell, JA
Jenab, M
Fedirko, V
Romieu, I
Aleksandrova, K
Overvad, K
Kyro, C
Tjonneland, A
Affret, A
His, M
Boutron-Ruault, MC
Katzke, V
Kuhn, T
Boeing, H
Trichopoulou, A
Naska, A
Kritikou, M
Saieva, C
Agnoli, C
Santucci de Magistris, M
Tumino, R
Fasanelli, F
Weiderpass, E
Skeie, G
Merino, S
Jakszyn, P
Sanchez, MJ
Dorronsoro, M
Navarro, C
Ardanaz, E
Sonestedt, E
Ericson, U
Nilsson, LM
Boden, S
Bueno-de-Mesquita, HB
Peeters, PH
Perez-Cornago, A
Wareham, NJ
Khaw, KT
Freisling, H
Cross, AJ
Riboli, E
Scalbert, A
Item Type: Journal Article
Abstract: Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development is still sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93–1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
Issue Date: 19-Jan-2017
Date of Acceptance: 5-Dec-2016
URI: http://hdl.handle.net/10044/1/43254
DOI: https://dx.doi.org/10.1002/ijc.30582
ISSN: 1097-0215
Publisher: Wiley
Start Page: 1836
End Page: 1844
Journal / Book Title: International Journal of Cancer
Volume: 140
Issue: 8
Copyright Statement: © 2016 UIC. This is the accepted version of the following article, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ijc.30582/abstract
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
P47328
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
flavonoids
diet
colorectal cancer
prospective cohort
EPIC
LIGNAN INTAKE
POLYPHENOLS
ASSOCIATIONS
CALIBRATION
PREVENTION
BIOMARKERS
RECURRENCE
HEALTH
Adult
Aged
Cell Proliferation
Colorectal Neoplasms
Diet
Dietary Supplements
Europe
European Continental Ancestry Group
Female
Flavonoids
Follow-Up Studies
Humans
Male
Middle Aged
Nutritional Status
Prospective Studies
Risk Factors
Surveys and Questionnaires
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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