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Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study

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Title: Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study
Authors: Huang, J
Zagai, U
Hallmans, G
Nyrén, O
Engstrand, L
Stolzenberg-Solomon, R
Duell, EJ
Overvad, K
Katzke, VA
Kaaks, R
Jenab, M
Young Park, J
Murillo, R
Trichopoulou, A
Lagiou, P
Bamia, C
Bradbury, KE
Riboli, E
Aune, D
Tsilidis, KK
Capellá, G
Agudo, A
Krogh, V
Palli, D
Panico, S
Weiderpass, E
Tjønneland, A
Olsen, A
Martínez, B
Redondo-Sanchez, D
Chirlaque, MD
Peeters, PHM
Regnér, S
Lindkvist, B
Naccarati, A
Ardanaz, E
Larrañaga, N
Boutron-Ruault, MC
Revours, V
Barré, A
Bueno-de-Mesquita, HB
Ye, W
Item Type: Journal Article
Abstract: The association between H. pylori infection and pancreatic cancer risk remains contro versial. We conducted a nested case-control study with 448 p ancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine wh ether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjus ted for matching factors and other potential confounders. Our results showed that panc reatic cancer risk was neither associated with H. pylori seropositivity (OR=0.96; 95% CI: 0.70, 1.31) nor C agA seropositivity (OR=1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR=0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR=1.35; 95% CI: 0.77, 2.37), and although based o n small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR=5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provid ed evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western Eur opean populations. However, the suggested association bet ween chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent ver ification in future studies, and, if confirmed, further studies on the underlying mechan isms.
Issue Date: 29-Dec-2016
Date of Acceptance: 22-Nov-2016
URI: http://hdl.handle.net/10044/1/43238
DOI: http://dx.doi.org/10.1002/ijc.30590
ISSN: 1097-0215
Publisher: Wiley
Start Page: 1727
End Page: 1735
Journal / Book Title: International Journal of Cancer
Volume: 140
Issue: 8
Copyright Statement: © 2016 UICC. This is the accepted version of the following article, which has been published in final form at http://dx.doi.org/10.1002/ijc.30590
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
P47328
Keywords: EPIC cohort
H. pylori infection
chronic corpus atrophic gastritis
nested case-control study
pancreatic cancer risk
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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