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Integrative genomics in cardiovascular medicine

Title: Integrative genomics in cardiovascular medicine
Authors: Ware, JS
Petretto, E
Cook, SA
Item Type: Journal Article
Abstract: Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and cardiac physiology. Going forward, the integration of comprehensive next-generation sequencing data sets with quantitative phenotypes at the molecular, cellular, and whole-heart level using advanced modelling approaches provides an unprecedented opportunity for cardiovascular science.
Issue Date: 27-Sep-2012
Date of Acceptance: 20-Sep-2012
URI: http://hdl.handle.net/10044/1/43143
DOI: https://dx.doi.org/10.1093/cvr/cvs303
ISSN: 1755-3245
Publisher: Oxford University Press (OUP)
Start Page: 623
End Page: 630
Journal / Book Title: Cardiovascular Research
Volume: 97
Issue: 4
Copyright Statement: © 2012 The Author. Published on behalf of the European Society of Cardiology. All rights reserved. For permissions please email: journals.permissions@oup.com.
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: SP/10/10/28431
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
CARDIAC & CARDIOVASCULAR SYSTEMS
Integrative genomics
FAMILIAL HYPERTROPHIC CARDIOMYOPATHY
SPONTANEOUSLY HYPERTENSIVE-RAT
RECOMBINANT INBRED STRAINS
GENE ASSOCIATION NETWORKS
CORONARY-ARTERY-DISEASE
QUANTITATIVE TRAIT LOCI
WIDE ASSOCIATION
COMPLEX TRAITS
EXPRESSION
MODELS
Animals
Cardiovascular Diseases
Gene Expression Profiling
Genetic Linkage
Genetic Variation
Genomics
Humans
Phenotype
Quantitative Trait Loci
Sequence Analysis, DNA
Cardiovascular System & Hematology
1102 Cardiovascular Medicine And Haematology
Publication Status: Published
Open Access location: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583255/
Appears in Collections:Clinical Sciences
National Heart and Lung Institute
Molecular Sciences



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