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An Atlas of human kinase regulation

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Title: An Atlas of human kinase regulation
Authors: Ochoa, D
Mindaugas, J
Lawrence, RT
El Debs, B
Selkrig, J
Typas, A
Villen, J
Santos, S
Beltrao, P
Item Type: Journal Article
Abstract: The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cues and swiftly determines appropriate cellular responses. However, our understanding of cellular decision-making has been limited by the small number of simultaneously monitored phospho- regulatory events. Here, we have estimated changes in activity in 215 human kinases in 399 condi- tions from a compilation of nearly 3 million phosphopeptide quantifications. This atlas identifies commonly regulated kinases as those that are central in the signaling network and defines the logic relationships between kinase pairs. Co-regulation along the conditions predicts kinase-complex and kinase-substrate associations. Additionally, the kinase regulation profile acts as a molecular fingerprint to identify related and opposing signaling states. Using this atlas, we identified essen- tial mediators of stem cell differentiation, modulators of Salmonella infection and new targets of AKT1. This provides a global view of human phosphorylation-based signaling and the necessary context to better understand kinase driven decision-making.
Issue Date: 1-Dec-2016
Date of Acceptance: 20-Oct-2016
URI: http://hdl.handle.net/10044/1/42872
DOI: https://dx.doi.org/10.15252/msb.20167295
ISSN: 1744-4292
Publisher: Wiley
Journal / Book Title: Molecular Systems Biology
Volume: 12
Issue: 12
Copyright Statement: © 2016 The Authors. Published under the terms of the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/)
Keywords: Bioinformatics
0699 Other Biological Sciences
Publication Status: Published
Article Number: 888
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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