Functional neuroimaging of visuo-vestibular interaction

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Title: Functional neuroimaging of visuo-vestibular interaction
Author(s): Roberts, RE
Arshad, Q
Patel, M
Dima, D
Leech, R
Seemungal, BM
Sharp, DS
Bronstein, AM
Item Type: Journal Article
Abstract: The brain combines visual, vestibular and proprioceptive information to distinguish between self-and world-motion. Often these signals are complementary and indicate that the individual is moving or stationary with respect to the surroundings. However, conflicting visual motion and vestibular cues can lead to ambiguous or false sensations of motion. In this study, we used functional magnetic resonance imaging to explore human brain activation when visual and vestibular cues were either complementary or in conflict. We combined a horizontally moving optokinetic stimulus with caloric irrigation of the right ear to produce conditions where the vestibular activation and visual motion indicated the same (congruent) or opposite directions of self-motion (incongruent). Visuo-vestibular conflict was associated with increased activation in a network of brain regions including posterior insular and transverse temporal areas, cerebellar tonsil, cingulate and medial frontal gyri. In the congruent condition there was increased activation in primary and secondary visual cortex. These findings suggest that when sensory information regarding self-motion is contradictory, there is preferential activation of multisensory vestibular areas to resolve this ambiguity. When cues are congruent there is a bias towards visual cortical activation. The data support the view that a network of brain areas including the posterior insular cortex may play an important role in integrating and disambiguating visual and vestibular cues.
Publication Date: 10-Dec-2016
Date of Acceptance: 19-Nov-2016
URI: http://hdl.handle.net/10044/1/42842
DOI: https://dx.doi.org/10.1007/s00429-016-1344-4
ISSN: 1863-2661
Publisher: Springer Verlag (Germany)
Start Page: 2329
End Page: 2343
Journal / Book Title: Brain Structure & Function
Volume: 222
Issue: 5
Sponsor/Funder: Medical Research Council (MRC)
National Institute for Health Research
Imperial College Trust
Funder's Grant Number: MR/J004685/1
NIHR-RP-011-048
n/a
Keywords: Caloric
Vestibular
Visual dependency
Visual motion
Visual–vestibular interaction
Neurology & Neurosurgery
1116 Medical Physiology
1109 Neurosciences
1702 Cognitive Science
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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