Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

File Description SizeFormat 
160122 Obon Santacana EJN.pdfAccepted version480.03 kBAdobe PDFView/Open
Title: Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort
Authors: Obón-Santacana, M
Lujan-Barroso, L
Freisling, H
Cadeau, C
Fagherazzi, G
Boutron-Ruault, MC
Kaaks, R
Fortner, RT
Boeing, H
Ramón Quirós, J
Molina-Montes, E
Chamosa, S
Castaño, JM
Ardanaz, E
Khaw, KT
Wareham, N
Key, T
Trichopoulou, A
Lagiou, P
Naska, A
Palli, D
Grioni, S
Tumino, R
Vineis, P
De Magistris, MS
Bueno-de-Mesquita, HB
Peeters, PH
Wennberg, M
Bergdahl, IA
Vesper, H
Riboli, E
Duell, EJ
Item Type: Journal Article
Abstract: PURPOSE: Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. RESULTS: The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. CONCLUSIONS: Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.
Issue Date: 5-Feb-2016
Date of Acceptance: 22-Jan-2016
ISSN: 1436-6215
Publisher: Springer Verlag
Start Page: 1157
End Page: 1168
Journal / Book Title: European Journal of Nutrition
Volume: 56
Issue: 3
Copyright Statement: © Springer-Verlag 2016. The final publication is available at Springer via
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
Hemoglobin adducts
1111 Nutrition And Dietetics
Publication Status: Published
Conference Place: Germany
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx