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On the characterisation of the heterogeneous mechanical response of human brain tissue

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Title: On the characterisation of the heterogeneous mechanical response of human brain tissue
Authors: Forte, AE
Gentleman, SM
Dini, D
Item Type: Journal Article
Abstract: The mechanical characterization of brain tissue is a complex task scientists have tried to accomplish for over fifty years. The results in literature often differ by orders of magnitude because of the lack of a standard testing protocol. Different testing conditions (inc luding humidity, temperature, strain rate), the methodology adopted , the variety of the species analysed, are all potential sources of discrepancies in the measurements. In this work we present a rigorous experimental investigation on the mechanical proper ties of human brain , covering both gr e y and white matter. The influence of testing conditions is also shown and thoroughly discussed. The material characterisation performed is finally adopted to provide inputs to a mathematical formulation suitable for nu merical s i mulations of brain deformation during surgical procedures .
Issue Date: 8-Dec-2016
Date of Acceptance: 20-Nov-2016
URI: http://hdl.handle.net/10044/1/42710
DOI: https://dx.doi.org/10.1007/s10237-016-0860-8
ISSN: 1617-7959
Publisher: Springer Verlag (Germany)
Start Page: 907
End Page: 920
Journal / Book Title: Biomechanics and Modeling in Mechanobiology
Volume: 16
Issue: 3
Copyright Statement: © The Author(s) 2016. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Commission of the European Communities
Engineering & Physical Science Research Council (E
Parkinson's UK
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 270460
EP/K503733/1
J-1402
EP/N025954/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Technology
Biophysics
Engineering, Biomedical
Engineering
Human brain tissue
Mechanical properties
Abaqus
FE modelling
Humidity and temperature
Heterogeneous
MAGNETIC-RESONANCE ELASTOGRAPHY
WHITE-MATTER
IN-VIVO
CONSTITUTIVE MODEL
LARGE-STRAIN
HEAD-INJURY
SHEAR
BEHAVIOR
HYDROCEPHALUS
BIOMECHANICS
Biomedical Engineering
0913 Mechanical Engineering
0903 Biomedical Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Mechanical Engineering
Bioengineering
Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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