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The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk

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Title: The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk
Authors: Kong, SY
Takeuchi, M
Hyogo, H
McKeown-Eyssen, G
Yamagishi, S-I
Chayama, K
O'Brien, PJ
Ferrari, P
Overvad, K
Olsen, A
Tjonneland, A
Boutron-Ruault, M-C
Bastide, N
Carbonnel, F
Kuehn, T
Kaaks, R
Boeing, H
Aleksandrova, K
Trichopoulou, A
Lagiou, P
Vasilopoulou, E
Masala, G
Pala, V
De Magistris, MS
Tumino, R
Naccarati, A
Bueno-De-Mesquita, HB
Peeters, PH
Weiderpass, E
Quiros, JR
Jakszyn, P
Sanchez, M-J
Dorronsoro, M
Gavrila, D
Ardanaz, E
Rutegard, M
Nystroem, H
Wareham, NJ
Khaw, K-T
Bradbury, KE
Romieu, I
Freisling, H
Stavropoulou, F
Gunter, MJ
Cross, AJ
Riboli, E
Jenab, M
Bruce, WR
Item Type: Journal Article
Abstract: Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1:1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82–1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.57–1.22; OR for rectal cancer, 1.90; 95% CI, 1.14–3.19; Pheterogeneity = 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development.
Issue Date: 24-Sep-2015
Date of Acceptance: 28-Jul-2015
URI: http://hdl.handle.net/10044/1/42694
DOI: http://dx.doi.org/10.1158/1055-9965.EPI-15-0422
ISSN: 1538-7755
Publisher: American Association for Cancer Research
Start Page: 1855
End Page: 1863
Journal / Book Title: Cancer Epidemiology Biomarkers & Prevention
Volume: 24
Issue: 12
Copyright Statement: ©2015 American Association for Cancer Research.
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Public, Environmental & Occupational Health
SOLUBLE RECEPTOR
ALCOHOL-CONSUMPTION
METABOLIC SYNDROME
RECTAL-CANCER
DIABETIC-RATS
NUTRITION
COLON
COMPLICATIONS
INFLAMMATION
ENDPRODUCTS
Case-Control Studies
Cohort Studies
Colorectal Neoplasms
Europe
Female
Glyceraldehyde
Glycosylation End Products, Advanced
Humans
Logistic Models
Male
Middle Aged
Prospective Studies
Risk Factors
Epidemiology
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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