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Tracking the impact of excisional cervical treatment on the cervix using biospectroscopy

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Title: Tracking the impact of excisional cervical treatment on the cervix using biospectroscopy
Authors: Kyrgiou, M
Item Type: Journal Article
Abstract: Local excisional treatment for cervical intra - epithelial neoplasia (CIN) is linked to significant adverse sequelae including preterm birth , with c one depth and radicality of treatment correlat ing to the frequency and severity of adverse events. Attenuated total reflect ion Fourier - transform infra red (ATR - FTIR) spectroscopy can detect underlying cervical disease more accurately than conventional cytology. The chemical profile of c ells pre - and post - treatment may differ as a result of altered biochemical processes due to excis ion , or treatment of the disease. Since pre - treatment cervi cal length var ies amongst women , the percentage of cervix excised may correlate more accurately to risk than absolute dimensions . We show that t reatment for CIN significantly alters the biochemistry of the cervix, compared with women who have not had treatment ; t his is due to the excision of cervical tissue rather than a disease - controlling effect . However, the spectra do seem to correlate to the cone depth or proportion of cervical lengt h excised. Future research should aim to explore the impact of treatment in a larger cohort.
Issue Date: 15-Dec-2016
Date of Acceptance: 16-Nov-2016
URI: http://hdl.handle.net/10044/1/42688
DOI: https://dx.doi.org/10.1038/srep38921
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 6
Copyright Statement: © 2016 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: British Society for Colposcopy and Cervical Pathology
Imperial College Healthcare Charity
Genesis Research Trust
Funder's Grant Number: N/A
7114/R17R
01020
Publication Status: Published
Article Number: 38921
Appears in Collections:Division of Surgery
Faculty of Medicine



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