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Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep.

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Title: Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep.
Authors: Clancy, NT
Saso, S
Stoyanov, D
Sauvage, V
Corless, DJ
Boyd, M
Noakes, DE
Thum, MY
Ghaem-Maghami, S
Smith, JR
Elson, DS
Item Type: Journal Article
Abstract: Uterine transplantation surgery (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility (AUFI) in the case of the congenital absence or surgical removal of the uterus. Successful surgical attachment of the organ and its associated vasculature is essential for the organ’s reperfusion and long-term viability. Spectral imaging techniques have demonstrated the potential for the measurement of hemodynamics in medical applications. These involve the measurement of reflectance spectra by acquiring images of the tissue in different wavebands. Measures of tissue constituents at each pixel can then be extracted from these spectra through modeling of the light–tissue interaction. A multispectral imaging (MSI) laparoscope was used in sheep and rabbit UTx models to study short- and long-term changes in oxygen saturation following surgery. The whole organ was imaged in the donor and recipient animals in parallel with point measurements from a pulse oximeter. Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Cornual oxygenation trends measured with MSI are consistent with pulse oximeter readings, showing decreased StO2 immediately after anastomosis of the blood vessels. Long-term results show recovery of StO2 to preoperative levels.
Issue Date: 27-Oct-2016
Date of Acceptance: 5-Oct-2016
URI: http://hdl.handle.net/10044/1/42511
DOI: https://dx.doi.org/10.1117/1.JBO.21.10.106006
ISSN: 1083-3668
Publisher: Society of Photo-optical Instrumentation Engineers (SPIE)
Journal / Book Title: Journal of Biomedical Optics
Volume: 21
Issue: 10
Copyright Statement: © 2016 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI: 10.1117/1.JBO.21.10.106006
Sponsor/Funder: National Institute for Health Research
Deutsche Forschungsgemeinschaft ( German Research Foundation
Imperial College London
Funder's Grant Number: II-LS-0511-21004
637960
Junior Research Fellowship
Keywords: Optics
0205 Optical Physics
1113 Ophthalmology And Optometry
0903 Biomedical Engineering
Publication Status: Published
Conference Place: United States
Open Access location: http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=2578413
Article Number: 106006
Appears in Collections:Division of Surgery



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