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Road traffic noise, blood pressure and heart rate: Pooled analyses of harmonized data from 88,336 participants

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Zijlema et al 2016 Env Res submitted version.pdfAccepted version473.77 kBAdobe PDFView/Open
Title: Road traffic noise, blood pressure and heart rate: Pooled analyses of harmonized data from 88,336 participants
Authors: Zijlema, W
Cai, Y
Doiron, D
Mbatchou, S
Fortier, I
Gulliver, J
Hoogh, KD
Morley, D
Hodgson, S
Elliott, P
Key, T
Kongsgard, H
Hveem, K
Gaye, A
Burton, P
Hansell, A
Stolk, R
Rosmalen, J
Item Type: Journal Article
Abstract: Introduction Exposure to road traffic noise may increase blood pressure and heart rate. It is unclear to what extent exposure to air pollution may influence this relationship. We investigated associations between noise, blood pressure and heart rate, with harmonized data from three European cohorts, while taking into account exposure to air pollution. Methods Road traffic noise exposure was assessed using a European noise model based on the Common Noise Assessment Methods in Europe framework (CNOSSOS-EU). Exposure to air pollution was estimated using a European-wide land use regression model. Blood pressure and heart rate were obtained by trained clinical professionals. Pooled cross-sectional analyses of harmonized data were conducted at the individual level and with random-effects meta-analyses. Results We analyzed data from 88,336 participants, across the three participating cohorts (mean age 47.0 (±13.9) years). Each 10 dB(A) increase in noise was associated with a 0.93 (95% CI 0.76;1.11) bpm increase in heart rate, but with a decrease in blood pressure of 0.01 (95% CI −0.24;0.23) mmHg for systolic and 0.38 (95% CI −0.53; −0.24) mmHg for diastolic blood pressure. Adjustments for PM10 or NO2 attenuated the associations, but remained significant for DBP and HR. Results for BP differed by cohort, with negative associations with noise in LifeLines, no significant associations in EPIC-Oxford, and positive associations with noise >60 dB(A) in HUNT3. Conclusions Our study suggests that road traffic noise may be related to increased heart rate. No consistent evidence for a relation between noise and blood pressure was found.
Issue Date: 28-Sep-2016
Date of Acceptance: 16-Sep-2016
URI: http://hdl.handle.net/10044/1/42471
DOI: https://dx.doi.org/10.1016/j.envres.2016.09.014
ISSN: 0013-9351
Publisher: Elsevier
Start Page: 804
End Page: 813
Journal / Book Title: Environmental Research
Volume: 151
Copyright Statement: © 2016 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Commission of the European Communities
Medical Research Council (MRC)
National Institute for Health Research
Public Health England
Medical Research Council
Funder's Grant Number: NF-SI-0611-10136
RDC01 79560
261433
MR/L01341X/1
RTJ6219303-1
N/A
Keywords: Air pollution
Blood pressure
Epidemiology
Heart rate
Meta-analysis
Noise
Toxicology
03 Chemical Sciences
05 Environmental Sciences
06 Biological Sciences
Notes: keywords: Blood pressure keywords: Blood pressure keywords: Blood pressure keywords: Blood pressure keywords: Blood pressure keywords: Blood pressure
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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