Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

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Title: Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort
Authors: Fanidi, A
Muller, DC
Midttun, Ø
Ueland, PM
Vollset, SE
Relton, C
Vineis, P
Weiderpass, E
Skeie, G
Brustad, M
Palli, D
Tumino, R
Grioni, S
Sacerdote, C
Bueno-de-Mesquita, HB
Peeters, PH
Boutron-Ruault, MC
Kvaskoff, M
Cadeau, C
Huerta, JM
Sánchez, MJ
Agudo, A
Lasheras, C
Quirós, JR
Chamosa, S
Riboli, E
Travis, RC
Ward, H
Murphy, N
Khaw, KT
Trichopoulou, A
Lagiou, P
Papatesta, EM
Boeing, H
Kuehn, T
Katzke, V
Steffen, A
Johansson, A
Brennan, P
Johansson, M
Item Type: Journal Article
Abstract: Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56-0.88, Ptrend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42-0.87). Low 25(OH)D3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk of HNC, as well as improved survival following diagnosis.
Issue Date: 4-Nov-2016
Date of Acceptance: 11-Oct-2016
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 6
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
Publication Status: Published
Open Access location:
Article Number: 36017
Appears in Collections:Epidemiology, Public Health and Primary Care

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