Anticancer Gene Transfer for Cancer Gene Therapy

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Title: Anticancer Gene Transfer for Cancer Gene Therapy
Authors: Pazarentzos, E
Mazarakis, ND
Item Type: Chapter
Abstract: Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have been developed that target cancer cells leaving normal cells unharmed. Here we review such cancer specific gene therapy systems currently used in the treatment of cancer and discuss the major challenges and future directions in this field.
Editors: Grimm, S
Issue Date: 31-Dec-2014
URI: http://hdl.handle.net/10044/1/42357
DOI: http://dx.doi.org/10.1007/978-1-4471-6458-6_13
ISBN: 978-1-4471-6457-9
Publisher: Springer
Start Page: 255
End Page: 280
Journal / Book Title: Anticancer Genes
Advances in Experimental Medicine and Biology
Volume: 818
Copyright Statement: © Springer Verlag 2014. The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4471-6458-6_13.
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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