A conducting polymer with enhanced electronic stability applied in cardiac models

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Title: A conducting polymer with enhanced electronic stability applied in cardiac models
Author(s): Mawad, D
Mansfield, C
Lauto, A
Perbellini, F
Nelson, G
Tonkin, J
Bello, S
Carrod, D
Micolich, A
Mahat, M
Simonotto, J
Payne, D
Lyon, A
Gooding, J
Harding, S
Terracciano, C
Stevens, MM
Item Type: Journal Article
Abstract: Electrically active constructs can have a beneficial effect on electroresponsive tissues, such as the brain, heart, and nervous system. Conducting polymers (CPs) are being considered as components of these constructs because of their intrinsic electroactive and flexible nature. However, their clinical application has been largely hampered by their short operational time due to a decrease in their electronic properties. We show that, by immobilizing the dopant in the conductive scaffold, we can prevent its electric deterioration. We grew polyaniline (PANI) doped with phytic acid on the surface of a chitosan film. The strong chelation between phytic acid and chitosan led to a conductive patch with retained electroactivity, low surface resistivity (35.85 ± 9.40 kilohms per square), and oxidized form after 2 weeks of incubation in physiological medium. Ex vivo experiments revealed that the conductive nature of the patch has an immediate effect on the electrophysiology of the heart. Preliminary in vivo experiments showed that the conductive patch does not induce proarrhythmogenic activities in the heart. Our findings set the foundation for the design of electronically stable CP-based scaffolds. This provides a robust conductive system that could be used at the interface with electroresponsive tissue to better understand the interaction and effect of these materials on the electrophysiology of these tissues.
Publication Date: 30-Nov-2016
Date of Acceptance: 27-Oct-2016
URI: http://hdl.handle.net/10044/1/42311
DOI: https://dx.doi.org/10.1126/sciadv.1601007
ISSN: 2375-2548
Publisher: American Association for the Advancement of Science
Journal / Book Title: Science Advances
Volume: 2
Issue: 11
Sponsor/Funder: Commission of the European Communities
British Heart Foundation
Wellcome Trust
Commission of the European Communities
Funder's Grant Number: PIIF-GA-2012-328897
RM/13/1/30157
098411/Z/12/Z
ERC-2013-CoG-616417
Copyright Statement: © 2016, The Authors This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Conducting polymer
bioadhesive
bioelectronic
cardiac
electronic stability
ex vivo
in vivo
optical mapping
Publication Status: Published
Article Number: e1601007
Appears in Collections:Faculty of Engineering
Materials
National Heart and Lung Institute
Faculty of Medicine
Faculty of Natural Sciences



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