Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

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Title: Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
Authors: Perez-Cornago, A
Appleby, PN
Tipper, S
Key, TJ
Allen, NE
Nieters, A
Vermeulen, R
Roulland, S
Casabonne, D
Kaaks, R
Fortner, RT
Boeing, H
Trichopoulou, A
La Vecchia, C
Klinaki, E
Hansen, L
Tjonneland, A
Bonnet, F
Fagherazzi, G
Boutron-Ruault, M
Pala, V
Masala, G
Sacerdote, C
Peeters, PH
Bueno-de-Mesquita, HB
Weiderpass, E
Dorronsoro, M
Ramon Quiros, J
Barricarte, A
Gavrila, D
Agudo, A
Borgquist, S
Rosendahl, AH
Melin, B
Wareham, N
Khaw, K
Gunter, M
Riboli, E
Vineis, P
Travis, RC
Item Type: Journal Article
Abstract: Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57–1.03], ptrend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.
Issue Date: 27-Dec-2016
Date of Acceptance: 31-Oct-2016
ISSN: 1097-0215
Publisher: Wiley
Start Page: 1111
End Page: 1118
Journal / Book Title: International Journal of Cancer
Volume: 140
Issue: 5
Copyright Statement: © 2016 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: University Medical Center Utrecht
Imperial College Trust
Funder's Grant Number: N/A
Keywords: EPIC cohort
nested case-control
non-Hodgkin lymphoma
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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