A lipophilic copper(II) complex as an optical probe for intracellular detection of NO

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Title: A lipophilic copper(II) complex as an optical probe for intracellular detection of NO
Author(s): Vilar Compte, R
Wilson, N
Mak, LH
Cilibrizzi, A
Gee, AD
Long, NJ
Woscholski, R
Item Type: Journal Article
Abstract: A new chemical sensor for cellular imaging of NO is presented. This cell - permeable probe is ba sed on a complex where copper(II) is coordinated to a tridentate ligand substituted with a fluorophore (NBD) and an octyl group . The fluorescent response of this complex towards a range of reactive species (namely NO, NO 2 - , NO 3 - , H 2 O 2 , ClO - , O 2 - and ONOO - ) has been studied in vitro showing that the probe is hig h ly selective for NO. The probe is readily taken up by cells and is able to image the cellular concentrations of NO
Publication Date: 18-Oct-2016
Date of Acceptance: 12-Oct-2016
URI: http://hdl.handle.net/10044/1/42191
DOI: https://dx.doi.org/10.1039/C6DT02880B
ISSN: 1477-9226
Publisher: Royal Society of Chemistry
Start Page: 18177
End Page: 18182
Journal / Book Title: Dalton Transactions
Volume: 45
Copyright Statement: © The Royal Society of Chemistry 2016
Keywords: Science & Technology
Physical Sciences
Chemistry, Inorganic & Nuclear
Chemistry
NITRIC-OXIDE SYNTHASE
LIVING CELLS
FLUORESCENT-PROBES
AQUEOUS-SOLUTION
VISUALIZATION
DISEASE
COBALT
Inorganic & Nuclear Chemistry
0302 Inorganic Chemistry
0399 Other Chemical Sciences
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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