Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography

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Title: Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
Authors: Esmail, H
Lai, RP
Lesosky, M
Wilkinson, KA
Graham, CM
Coussens, AK
Oni, T
Warwick, JM
Said-Hartley, Q
Koegelenberg, CF
Walzl, G
Flynn, JL
Young, DB
Barry Iii, CE
O'Garra, A
Wilkinson, RJ
Item Type: Journal Article
Abstract: Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
Issue Date: 5-Sep-2016
Date of Acceptance: 8-Jul-2016
URI: http://hdl.handle.net/10044/1/42188
DOI: https://dx.dox.org/10.1038/nm.4161
ISSN: 1546-170X
Publisher: Nature Publishing Group
Journal / Book Title: Nature Medicine
Volume: 22
Copyright Statement: © 2016 Nature America, Inc. All rights reserved.
Keywords: Immunology
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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