Exosomes and Exosomal miRNA in Respiratory Diseases

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Title: Exosomes and Exosomal miRNA in Respiratory Diseases
Authors: Alipoor, SD
Mortaz, E
Garssen, J
Movassaghi, M
Mirsaeidi, M
Adcock, IM
Item Type: Journal Article
Abstract: Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly miRNAs, to both neighboring and distal cells, they are considered important in cell-cell communication. Recent evidence has shown their possible importance in the pathogenesis of several pulmonary diseases. The differential expression of exosomes and of exosomal miRNAs in disease has driven their promise as biomarkers of disease enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools. In this review, we summarize recent advances in this area as applicable to pulmonary diseases.
Issue Date: 25-Sep-2016
Date of Acceptance: 28-Aug-2016
ISSN: 1466-1861
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Mediators of Inflammation
Volume: 2016
Copyright Statement: © 2016 Shamila D. Alipoor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 093080/Z/10/Z
Keywords: Immunology
1107 Immunology
Publication Status: Published
Article Number: 5628404
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine

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