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After Ebola in West Africa - Unpredictable Risks, Preventable Epidemics

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Title: After Ebola in West Africa - Unpredictable Risks, Preventable Epidemics
Author(s): Agua-Agum, J
Allegranzi, B
Ariyarajah, A
Aylward, RB
Blake, IM
Barboza, P
Bausch, D
Brennan, RJ
Clement, P
Coffey, P
Cori, A
Donnelly, CA
Dorigatti, I
Drury, P
Durski, K
Dye, C
Eckmanns, T
Ferguson, NM
Fraser, C
Garcia, E
Garske, T
Gasasira, A
Gurry, C
Gutierrez, GJ
Hamblion, E
Hinsley, W
Holden, R
Holmes, D
Hugonnet, S
Jombart, T
Kelley, E
Santhana, R
Mahmoud, N
Mills, HL
Mohamed, Y
Musa, E
Naidoo, D
Nedjati-Gilani, G
Newton, E
Norton, I
Nouvellet, P
Perkins, D
Perkins, M
Riley, S
Schumacher, D
Shah, A
Minh, T
Varsaneux, O
Van Kerkhove, MD
Item Type: Journal Article
Abstract: Between December 2013 and April 2016, the largest epidemic of Ebola virus disease (EVD) to date generated more than 28,000 cases and more than 11,000 deaths in the large, mobile populations of Guinea, Liberia, and Sierra Leone. Tracking the rapid rise and slower decline of the West African epidemic has reinforced some common understandings about the epidemiology and control of EVD but has also generated new insights. Despite having more information about the geographic distribution of the disease, the risk of human infection from animals and from survivors of EVD remains unpredictable over a wide area of equatorial Africa. Until human exposure to infection can be anticipated or avoided, future outbreaks will have to be managed with the classic approach to EVD control — extensive surveillance, rapid detection and diagnosis, comprehensive tracing of contacts, prompt patient isolation, supportive clinical care, rigorous efforts to prevent and control infection, safe and dignified burial, and engagement of the community. Empirical and modeling studies conducted during the West African epidemic have shown that large epidemics of EVD are preventable — a rapid response can interrupt transmission and restrict the size of outbreaks, even in densely populated cities. The critical question now is how to ensure that populations and their health services are ready for the next outbreak, wherever it may occur. Health security across Africa and beyond depends on committing resources to both strengthen national health systems and sustain investment in the next generation of vaccines, drugs, and diagnostics.
Publication Date: 11-Aug-2016
Date of Acceptance: 1-Aug-2016
URI: http://hdl.handle.net/10044/1/42037
DOI: http://dx.doi.org/10.1056/NEJMsr1513109
ISSN: 1533-4406
Publisher: Massachusetts Medical Society
Start Page: 587
End Page: 596
Journal / Book Title: New England Journal of Medicine
Volume: 375
Issue: 6
Copyright Statement: From N Engl J Med 2016; 375:587-596. © 2016 Massachusetts Medical Society. Reprinted with permission.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: G0600719B
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
VIRUS DISEASE OUTBREAK
SEXUAL TRANSMISSION
MODELING ANALYSIS
RAPID RESPONSE
SEPTEMBER 2014
SIERRA-LEONE
REMOTE AREAS
LIBERIA
INTERVENTIONS
DYNAMICS
Africa, Western
Disaster Planning
Ebolavirus
Epidemics
Hemorrhagic Fever, Ebola
Humans
Public Health Administration
WHO Ebola Response Team
Humans
Hemorrhagic Fever, Ebola
Disaster Planning
Public Health Administration
Africa, Western
Ebolavirus
Epidemics
General & Internal Medicine
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Epidemiology, Public Health and Primary Care



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